Question No:1
Sickle cell anaemia caused by substitution of Glutamic acid (Glue) by _____ at the sixth position of the beta globin chain of the haemoglobin molecule,
[A] Asn (Aspargine)
[B] Gly(Glycine)
[C] Arg (Argenine)
[D] Val (Valine)
Question No:2
Which enzyme is defective in PKU?
(A) DOPA Enzyme(1) -> Melanin
(B) Tyrosine Enzyme(2) -> Thyroxin
(C) Phenylalanine Enzyme(3) -> tyrosine
(D) Tyrosine Enzyme(4) -> Homogentisic acid
[A] Enzyme
[B] Enzyme
[C] Enzyme
[D] Enzyme
Question No:3
True about Phenyllketonuria
[A] Metal retardation
[B] Accumulation of phenylalanine and phenyl pyruvic acid and other derivatives
[C] Autosomal recessive trait
[D] All of the above
Question No:4
The substitution of amino acid in the globin protein results due to the single bass substitution at the sixth codon of the beta globin gene from,
[A] GAG to GGG
[B] CAG to GAG
[C] GAG to GUG
[D] GGC to GGA
Question No:5
Which of the following amino acid not present in first six amino acids in affected beta-chain of Haemoglobin?
[A] Val
[B] Thr
[C] Glu
[D] Leu
Question No:6
Name the amino acid which has its 2 molecules present in the first 7 amino acid of beta-chain of haemoglobin.
[A] Val
[B] His
[C] Leu
[D] Glu
Question No:7
Probability of which of the following is extremely rare?
[A] Carrier female in haemophilia
[B] Carrier male in haemophilia
[C] Affected male in haemophilia
[D] Affected female in haemophilia
Question No:8
In hemophilia how many proteins that is a part of the cascade of protein involved in clotting of blood affected?
[A] One
[B] Two
[C] Three
[D] Multiple/many
Question No:9
Diseased phenotype in sickle cell anaemia is shown by which of the following genotype?
[A] Hb AHb A
[B] HbsHbs
[C] Hb A Hb s
[D] All of above
Question No:10
Variation in DNA is due to
[A] Mutation
[B] Recombination
[C] Both (a) and (b)
[D] None of these
Question No:11
Alteration in chromosome may be due to
[A] Deletion of a segment of DNA
[B] Addition of segment of DNA
[C] Duplication of segment of DNA
[D] Any of above
Question No:12
Deletion or insertion of base pairs of DNA causes
[A] Point mutation
[B] Frameshift mutation
[C] Transversion
[D] All of the above
Question No:13
Find out correct statement.
[A] UV radiation can cause mutation in organism
[B] Chromosomal aberration are commonly observed in cancer cells
[C] Mutation is a phenomenon which results in alteration of DNA sequences and results in changes in the genotype and the phenotype of an organism
[D] All of the above
Question No:14
Mutation arises due to the change in single base pair of DNA is known as
[A] Point mutation
[B] Frameshift mutation
[C] Silent mutation
[D] Recombination
Question No:15
Classical example of point mutation is
[A] Haemophilia
[B] Sickle cell anaemia
[C] Mangolism
[D] Cri-du chat syndrome
Principles of Inheritance and Variation Mock Test-9
CategoriesNEET Biology